Gastric epithelial cell turnover, mucus production, and healing of gastric ulcers with carbenoxolone.
نویسندگان
چکیده
Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastric DNA loss and NANA secretion; the lower the cell turnover the higher the NANA production. In gastric ulcer patients DNA loss or turnover was significantly (p less than 0-01) higher than normal, and fell significantly (p less than 0-01) after four weeks' treatment with carbenoxolone when 16 of the 17 ulcers had healed. At the same time NANA output increased significantly (p less than 0-01). It is suggested that patients with gastric ulcer lose cells at a high rate, a state of affairs which is returned towards normal by carbenoxolone, thus allowing the epithelial cells to mature within the mucosa and produce more mucus.
منابع مشابه
Mucosal changes in gastric ulceration and their response to carbenoxolone sodium.
The epithelial differences between the normal stomach (six subjects) and 47 patients with gastric ulcers were compared. The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied. There is a statistically significant reduction in the total number of ...
متن کاملMorphological observations on gastric ulcers treated with carbenoxolone sodium.
Carbenoxolone, being a pentacyclic triterpene, is a drug which has a steroid-like structure, and despite anitiinflammatory and mineralocorticoid-like effects resembling those of steroid has shown considerable success in producing healing of gastric ulceration (Doll, Hill, Hutton, and Underwood, 1962; Horwich and Galloway, 1965). The mode of action of carbenoxolone is not yet understood. The dru...
متن کاملEffects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats
Alchornea triplinervia (Spreng.) Muell. Arg (Euphorbiaceae) is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. We previously described the gastroprotective action of methanolic extract (ME) of Alchornea triplinervia and the ethyl acetate fraction (EAF) in increasing of prostaglandin E₂ (PGE₂) gastric levels in the mucosa. In thi...
متن کاملA controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer.
Carbenoxolone sodium is an effective agent promoting the healing of chronic gastric ulcers (Doll, Hill, Hutton, and Underwood, 1962; Doll, Hill, and Hutton, 1965; Horwich and Galloway, 1965; Turpie and Thomson, 1965). The drug is readily absorbed from the stomach and is largely excreted in bile (Iveson, Parke, and Williams, 1966). It is believed to have a local effect on the gastric mucosa thro...
متن کاملGastroprotective Effect of Hydroalcoholic Extract of Aloe buettneri
Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 ml/kg body weight), after pre-treatment with indomethacin (300 mg/kg) or by utilising L-NA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 18 10 شماره
صفحات -
تاریخ انتشار 1977